p-Toluenesulfonyl chloride 对甲苯磺酰氯

规格: 99%
CAS: 98-59-9
产品编号: H48108
MDL: MFCD00007450
品牌: INFI
Chemical NameTosyl chloride
CAS Number98-59-9
MDL NumberMFCD00007450
EC Number202-684-8
Beilstein Registry Number607898
Synonym 4-Methylphenylsulfonyl chloride 4-TOLUENESULFONYL CHLORIDE 4-Toluene sulfochloride; 4-Methylbenzenesulfonyl chloride; p-Toluenesulfonyl chloride; Toluene-4-sulfonyl chloride; 4-Toluolsulfonyl ch 4-Toluenesulfonyl chloride 4-methylbenzenesulfonyl chloride 4-甲基苯磺酰氯 4-甲苯磺酰基氯 p-Methylphenylsulfonyl chloride p-Toluenesulfonyl ch p-Tosyl chloride p-toluolsulfonylchloride Benzenesulfonyl chloride, 4-methyl- P-TOLUENESULFONYL CHLORI TOLUENE-4-SULFONYL CHLORIDE TOS-CL Toluene-4-sulfonyl chloride Tosyl chloride Tosylchloride {} {} { 对氯化甲苯砜 对甲苯磺酰氯
PubChem Substance ID7397
Merck Number9534
Chemical Name Translation对甲苯磺酰氯(瓶装500g)
LabNetwork Molecule IDLN00173802
GHS Symbol
Warnings 危化品目录(2015) IRRITANT
Signal word Danger
WGK Germany1
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
    Risk Statements
    • R29 Contact with water liberates toxic gas. 遇水释放出有毒气体
    • R34 Causes burns 会导致灼伤
    • R38 Irritating to skin 刺激皮肤
    • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
      Precautionary statements
      • P234 Keep only in original container. 只保留在原来的容器中。
      • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
      • P273 Avoid release to the environment. 避免释放到环境中。
      • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
      • P301+P330+P331+P310
      • P303+P361+P353
      • P303+P361+P353+P310+P363
      • P304+P340
      • P304+P340+P310
      • P305+P351+P338
      • P305+P351+P338+P310
      • P390 Absorb spillage to prevent material damage. 吸收溢出物,防止重大损害。
      • P405 Store locked up. 上锁保管。
      • P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
      • P501 Dispose of contents/container to..… 处理内容物/容器.....
        Hazard statements
        • H290 May be corrosive to metals 可能腐蚀金属。
        • H315 Causes skin irritation 会刺激皮肤
        • H318 Causes serious eye damage 严重伤害眼睛
        • H317 May cause an allergic skin reaction 可能导致皮肤过敏
          Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
          Packing GroupII
          UN Number 3261 UN 3261 8/PG 2
          Storage condition Moisture Sensitive Store at RT. 密封保存。 充氩保存
          Hazard Codes 8
          Hazard Class8
        • 有机合成,染料、测定伯、仲胺类、酚类。
        • {ALF} Dehydrating agent, e.g. for conversion of ureas to carbodiimides: Org. Synth. Coll., 5, 555 (1973); Synthesis, 520 (1987).
        • {ALF} For a detailed study of the optimum conditions for the tosylation of primary and secondary alcohols in pyridine, see: J. Org. Chem., 51, 2386 (1986). For use of 1,4-Diazabicyclo[2.2.2]octane, A14003, as an alternative to pyridine in the tosylation of alcohols, see: Synthesis, 1433 (1997). In the presence of a carboxylic acid, the ester is formed in high yield: J. Am. Chem. Soc., 77, 6214 (1955); 79, 2146 (1957). Esterification of an unprotected amino acid can be effected by heating the tosylate salt with tosyl chloride in an alcohol solvent: J. Org. Chem., 48, 121 (1983).
        • {ALD} Merck: 14,9534
        • Beilstein:11,103
        • {uni_hamburg} Short: III/31b
        • {uni_hamburg} Short: III/20b
        • {ALF} In the presence of strong bases, 1,2-diols can be converted to epoxides: Synthesis, 706 (1977); 983 (1985); Synth. Commun., 23, 285 (1993), and 1,3-diols to oxetanes: Synthesis, 550 (1981).
        • {ALD} Merck: 14,9534
        • {ALF} N-Tosylation has been used to block the imidazole nucleus in histidine: Bull. Chem. Soc. Jpn., 42, 1466 (1969); 47, 3146 (1974), and arginine residues: Experientia, 24, 661 (1968), during peptide synthesis. Cleavage can be effected with HF. See Appendix 6.
        • {uni_hamburg} Short: II/2
        • 98-59-9 H48108 p-Toluenesulfonyl chloride


          Mol. FormulaC7
          Mol. Weight191
          Boiling Point134
          Vapor Pressure1 mmHg ( 88 °C)
          Melting Point65-69
          Flash Point128°(262°F)
          SolubilitySoluble in alcohol, benzene, and ether. Insoluble in water
          Mol. FormulaC7
          Mol. Weight191.00