p-Toluenesulfonyl chloride 对甲苯磺酰氯

规格: 99%
CAS: 98-59-9
产品编号: H48108
MDL: MFCD00007450
品牌: INFI
Chemical NameTosyl chloride
CAS Number98-59-9
Alfabeta NameMETHYLBENZENESULFONYLCHLORIDE 4-
MDL NumberMFCD00007450
EC Number202-684-8
Beilstein Registry Number607898
Synonym 4-Methylphenylsulfonyl chloride 4-TOLUENESULFONYL CHLORIDE 4-Toluene sulfochloride; 4-Methylbenzenesulfonyl chloride; p-Toluenesulfonyl chloride; Toluene-4-sulfonyl chloride; 4-Toluolsulfonyl ch 4-Toluenesulfonyl chloride 4-methylbenzenesulfonyl chloride 4-甲基苯磺酰氯 4-甲苯磺酰基氯 p-Methylphenylsulfonyl chloride p-Toluenesulfonyl ch p-Tosyl chloride p-toluolsulfonylchloride Benzenesulfonyl chloride, 4-methyl- P-TOLUENESULFONYL CHLORI TOLUENE-4-SULFONYL CHLORIDE TOS-CL Toluene-4-sulfonyl chloride Tosyl chloride Tosylchloride {} {} { 对氯化甲苯砜 对甲苯磺酰氯
PubChem Substance ID7397
Merck Number9534
Reaxys-RN607898
Chemical Name Translation对甲苯磺酰氯(瓶装500g)
LabNetwork Molecule IDLN00173802
InChIInChI=1S/C7H7ClO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3
GHS Symbol
Warnings 危化品目录(2015) IRRITANT
Signal word Danger
WGK Germany1
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
    Risk Statements
    • R29 Contact with water liberates toxic gas. 遇水释放出有毒气体
    • R34 Causes burns 会导致灼伤
    • R38 Irritating to skin 刺激皮肤
    • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
      Precautionary statements
      • P234 Keep only in original container. 只保留在原来的容器中。
      • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
      • P273 Avoid release to the environment. 避免释放到环境中。
      • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
      • P301+P330+P331+P310
      • P303+P361+P353
      • P303+P361+P353+P310+P363
      • P304+P340
      • P304+P340+P310
      • P305+P351+P338
      • P305+P351+P338+P310
      • P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
      • P405 Store locked up. 上锁保管。
      • P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
      • P501 Dispose of contents/container to..… 处理内容物/容器.....
        Hazard statements
        • H290 May be corrosive to metals 可能腐蚀金属。
        • H315 Causes skin irritation 会刺激皮肤
        • H318 Causes serious eye damage 严重伤害眼睛
        • H317 May cause an allergic skin reaction 可能导致皮肤过敏
          Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
          RTECSDB8929000
          Packing GroupII
          UN Number 3261 UN 3261 8/PG 2
          Storage condition Moisture Sensitive Store at RT. 密封保存。 充氩保存
          Hazard Codes 8
          Hazard Class8
        • 有机合成，染料、测定伯、仲胺类、酚类。
        • {ALF} Dehydrating agent, e.g. for conversion of ureas to carbodiimides: Org. Synth. Coll., 5, 555 (1973); Synthesis, 520 (1987).
        • {ALF} For a detailed study of the optimum conditions for the tosylation of primary and secondary alcohols in pyridine, see: J. Org. Chem., 51, 2386 (1986). For use of 1,4-Diazabicyclo[2.2.2]octane, A14003, as an alternative to pyridine in the tosylation of alcohols, see: Synthesis, 1433 (1997). In the presence of a carboxylic acid, the ester is formed in high yield: J. Am. Chem. Soc., 77, 6214 (1955); 79, 2146 (1957). Esterification of an unprotected amino acid can be effected by heating the tosylate salt with tosyl chloride in an alcohol solvent: J. Org. Chem., 48, 121 (1983).
        • {ALD} Merck: 14,9534
        • Beilstein:11,103
        • {uni_hamburg} Short: III/31b
        • {uni_hamburg} Short: III/20b
        • {ALF} In the presence of strong bases, 1,2-diols can be converted to epoxides: Synthesis, 706 (1977); 983 (1985); Synth. Commun., 23, 285 (1993), and 1,3-diols to oxetanes: Synthesis, 550 (1981).
        • {ALD} Merck: 14,9534
        • {ALF} N-Tosylation has been used to block the imidazole nucleus in histidine: Bull. Chem. Soc. Jpn., 42, 1466 (1969); 47, 3146 (1974), and arginine residues: Experientia, 24, 661 (1968), during peptide synthesis. Cleavage can be effected with HF. See Appendix 6.
        • {uni_hamburg} Short: II/2
          • 98-59-9 H48108 p-Toluenesulfonyl chloride 对甲苯磺酰氯

          化学属性

          Mol. FormulaC7
          Mol. Weight191
          Density1.4
          Boiling Point134
          Vapor Pressure1 mmHg ( 88 °C)
          Melting Point65-69
          Flash Point128°(262°F)
          SolubilitySoluble in alcohol, benzene, and ether. Insoluble in water
          TSCAYes
          Stability对湿度敏感
          Density1.4
          Mol. FormulaC7
          Mol. Weight191.00